Polycomb Repressive Complex 2 (PRC2) is a key epigenetic regulator complex that acts as a gene silencer to maintain cell identity, depositing the repressive histone H3 K27 trimethylation mark at target genes. Faulty PRC2 regulation is involved in developmental disorders and cancer development, but mechanisms that direct PRC2 activity to target genes are poorly understood. I am working with Trinity to understand the regulatory mechanisms at play in PRC2 and enable further insights into its localization and catalytic function.