Tjian + Darzacq Group
Publications
Unstructured transcription factor interactions enable emergent specificity
Abidi, A, C Cattoglio, N Tang, V Fan, G Dailey, A Hay, P Kunamaneni, D Milkie, X Darzacq, E Betzig, R Tjian, and T Graham. 2026. “Unstructured transcription factor interactions enable emergent specificity.” Science.
Short activation domains control chromatin association of transcription factors
Fan, V, A Abidi, T Graham, X Darzacq, and M Staller. 2026. “Short activation domains control chromatin association of transcription factors.” Elife (2026 Jan 9;15:e105776).
FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity
Ladewig, E, A Nazir, T Park, V Fan, Z Cao, J Hawk, L Kelly, R Tjian, C Leslie, and C Sawyers. 2026. “FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity.” Cell Reports, 45(2):116950.
Mission
Our research is devoted to understanding the molecular mechanisms that regulate gene expression, transcription, and genome organization in living cells.
Our mission is to advance fundamental discoveries in gene regulation while training the next generation of scientists through collaboration, innovation, and rigorous research.